Methods and compositions for enhancing collagen and proteoglycan synthesis in the skin
US7598291B2 · kind B2 · utility
Inventors
Key dates
| Filing date | Sep 2, 2004 |
| Grant date | Oct 6, 2009 |
| Priority date | — |
| Expiry date | Mar 9, 2026 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2800/522
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid, a lipoic acid analogue or derivative, a bioflavonoid, a constituent of ginkgo, or an isoflavone. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.