3,4-methylenedioxy-substituted chalcones as therapeutic agents

US7598294B2 · kind B2 · utility

Assignee

• Spear Therapeutics Limited · GB

Inventors

• Gerard Andrew Potter · Leicester, GB
• Paul Butler · Coalville, GB

Key dates

• Filing date: Sep 30, 2002
• Grant date: Oct 6, 2009
• Expiry date: Nov 16, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/65517
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention pertains to the use of a compounds for the manufacture of a medicament for use in the treatment of a proliferative condition, wherein the compounds have the following formula:wherein: each of RB2, RB3, RB4, and RB5 is independently —H, —OH, or —OMe; each of R1 and R2 is independently: —H, optionally substituted C1-4alkyl, or optionally substituted C5-20aryl; RA3 is —H, —OH, —OC(═O)RE, —OS(═O)2OH, or —OP(═O)(OH)2; RE is: —H, optionally substituted C1-6alkyl, optionally substituted C3-20 heterocyclyl, or optionally substituted C5-20aryl; or a pharmaceutically acceptable salt, solvate, amide, ester, ether, chemically protected form, or prodrug thereof. The present invention also pertains to such compounds, pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, for both diagnosis and treatment of, for example, proliferative conditions, such as cancer, and inflammatory conditions.