Host cells obtained by introducing and expressing VHL gene in cancer cells or embryonic stem cells
US7601344B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Dec 19, 2006 |
| Grant date | Oct 13, 2009 |
| Priority date | — |
| Expiry date | Oct 30, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2510/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to host cells that can function as neurons which are obtained by introducing and expressing von Hippel-Lindau gene in cancer cells, such as neuroblastoma cells and anaplastic oncocytes derived from the nerve system, or embryonic stem cells. The obtained hosts that have grown in vitro are grafted to the central nerve system or peripheral nerves to take so as to allow the host cells to function as neurons, thereby treating intractable neuronal diseases associated with neurological functional disorder, such as Parkinson's disease, amyotrophic lateral sclerosis, Huntington's chorea, Alzheimer's disease, brain infarction, spinal cord injury, brain contusion or malignant tumor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.