Genome mapping of functional DNA elements and cellular proteins

US7601492B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Xiang Fu · San Diego, US
• Young Soo Kwon · Seoul, KR

Key dates

• Filing date: Jul 2, 2004
• Grant date: Oct 13, 2009
• Expiry date: May 1, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q1/6837
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The disclosure provides methods of examining the binding of proteins to DNA across a genome (e.g., the entire genome or a portion thereof, such as one or more chromosomes or a chromosome regions). In particular, the disclosure relates to a method of identifying a regulatory region (e.g., a protein or enhancer region) of genomic DNA to which a protein of interest binds. In one aspect, the disclosure looks at tissue related regulation. In another aspect, the disclosure looks at developmental related regulation. In yet another aspect, the disclosure looks at regulation of expression in a particular disease state or disorder.