Methods and apparatus for screening and detecting multiple genetic mutations
US7601493B2 · kind B2 · utility
1Cited by
91References
17Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 24, 2003 |
| Grant date | Oct 13, 2009 |
| Priority date | — |
| Expiry date | Jan 18, 2024 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/143333
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
An assay system and methods are described where patient samples containing genomic DNA are analyzed for the presence of known genetic polymorphisms using a universal reporter strategy. In a preferred embodiment, the amplified DNA is localized at test sites in an array of sites on a microchip followed by a series of hybridization reactions that screen for the presence of a single mutation from among a number of mutations, and allow the identification of specific mutations. In addition to universal reporters, the assay may use blockers and discriminators for screening and identification of known polymorphisms.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.