Dutpase Inhibitors

US7601702B2 · kind B2 · utility

Assignee

• MEDIVIR AB · SE

Inventors

• Ian Gilbert · Dundee, GB
• Corinne Nguyen · Cardiff, GB
• Gian Filippo Ruda · Dundee, GB
• Alessandro Schipani · Dundee, GB
• Ganasan Kasinathan · Cardiff, GB
• Nils-Gunnar Johansson · Huddinge, SE
• Dolores Gonzalez Pacanowska · Granada, ES

Key dates

• Filing date: Jan 6, 2005
• Grant date: Oct 13, 2009
• Expiry date: May 5, 2026

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Deoxyuridine derivatives of Formula (I′); where A is O, S or CH2; B is O, S or CHR3; R1 is H, or various substituents; R2 is H, F; R3 is H, F, OH, NH2; or R2 and R3 together form a chemical bond; D is —NHCO—, —CONH—, —O—, —C(═O)—, —CH═CH, —C≡C—, —NR5—; R4 is hydrogen or various substituents; R5 is H, C1-C4 alkyl, C1-C4 alkanoyl; E is Si or C; R6, R7 and R8 are independently selected from C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, or a stable monocyclic, bicyclic or tricyclic ring system have utility in the prophylaxis of treatment of parasitic diseases such as malaria.