Process for synthesizing oil and surfactant-free hyaluronic acid nanoparticles and microparticles
US7601704B2 · kind B2 · utility
1Cited by
2References
34Claims
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Key dates
| Filing date | Nov 3, 2004 |
| Grant date | Oct 13, 2009 |
| Priority date | — |
| Expiry date | Jan 19, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08J2305/08
- WIPO fieldOther special machines
- WIPO sectorMechanical engineering
Abstract
A method for synthesizing uniformly sized hyaluronic acid (“HA”) particles that are substantially free from oil and surfactant contaminants. The method comprises crosslinking HA chains with 1-ethyl-3-(3-dimethlyaminopropyl) carbodiimide hydrochloride (“EDAC”) and adipic acid dihydrazide in a water/acetone mixture.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.