Crystalline form of 5(S)-(2-hydroxyethoxy)-20(S)-camptothecin

US7601732B2 · kind B2 · utility

Assignee

• DR. REDDY'S LABORATORIES LIMITED · IN

Inventors

• Venkateswarlu Akella · Darsi, IN
• Shanavas Alikunju · Darsi, IN
• Ajaya Kumar Reka · Hyderabad, IN
• Ramesh Mullangi · Bengaluru, IN
• Raju Sirisilla · Hyderabad, IN
• Subrahmanyam Duvvuri · Hyderabad, IN
• Sriram Rajagopal · Darsi, IN

Key dates

• Filing date: May 24, 2007
• Grant date: Oct 13, 2009
• Expiry date: May 24, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A crystalline form of 5(S)-(2′-hydroxyethoxy)-20(S)-camptothecin diastereoisomer of 5(RS)-(2′-hydroxyethoxy)-20(S)-camptothecin is described that is characterized by having an X-ray powder diffraction pattern comprising one or more peak intensities expressed in degrees 2θ that are selected from the group consisting of 7.2±0.1, 9.4±0.1, 11.02±0.1, 12.00±0.1, 14.54±0.1, 15.2±0.1, 18.92±0.1, 21.86±0.1, 22.74±0.1 and 26.42±0.1. Methods of making and using the compound are also described.