Process for making montelukast and intermediates therefor
US7601741B2 · kind B2 · utility
1Cited by
11References
19Claims
0Family size
Assignee
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Key dates
| Filing date | Nov 20, 2006 |
| Grant date | Oct 13, 2009 |
| Priority date | — |
| Expiry date | Nov 29, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The reaction of methylmagnesium halide is improved by the presence of a cerium (III) salt such as cerium trichloride. The reactions are typically associated with the production of montelukast, a pharmaceutically useful compound of the following formulaand salts thereof. Further enhancements can be derived from certain intermediates, salts thereof and/or purification thereof before and/or after the reaction involving methylmagnesium halide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.