Small molecule inhibition of a PDZ-domain interaction
US7601750B2 · kind B2 · utility
1Cited by
5References
25Claims
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Key dates
| Filing date | Oct 11, 2006 |
| Grant date | Oct 13, 2009 |
| Priority date | — |
| Expiry date | Oct 11, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D209/18
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel compounds that have been found effective in inhibiting PDZ domain interactions, and particularly interactions of PDZ domains in MAGIs with the oncogenic (tumor suppressor) protein PTEN and interactions between the PDZ domain in the Dishevelled (Dvl) protein and other proteins such as the Frizzled (Fz) protein, have the general formulaThe invention also includes combinatorial libraries, arrays and methods for screening and studying proteins using such compounds.Compounds of the invention have produced apoptosis in certain cell lines that overexpress the Dishevelled protein (Dvl); inhibiting Wnt signaling.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.