Nucleic acid inhibitors of glutamate receptors
US7601823B2 · kind B2 · utility
1Cited by
1References
6Claims
0Family size
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Key dates
| Filing date | Oct 24, 2005 |
| Grant date | Oct 13, 2009 |
| Priority date | — |
| Expiry date | Nov 9, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/16
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to novel nucleic acid ligands or aptamers that bind to and inhibit the activation of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors. Also disclosed is a novel combination of technologies, i.e., SELEX and laser pulse photolysis for the selection and screening of aptamers that inhibit receptor function and are useful therefore, in the treatment of diseases associated with excessive activation of ionotropic glutamate receptors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.