Preparation and purification of 4-(indazol-3-yl)phenols
US7601847B2 · kind B2 · utility
0Cited by
2References
21Claims
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Assignee
Inventors
Key dates
| Filing date | Oct 24, 2005 |
| Grant date | Oct 13, 2009 |
| Priority date | — |
| Expiry date | Mar 28, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D231/56
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention concerns processes for the production and purification of compounds of the formula:where R1-R10 are as defined in the specification. Preferred processes of the invention utilize a lithium bis(trimethylsilyl)amide, lithium dicyclohexylamide, or potassium bis(trimethylsilyl)amide base and a R1—X alkylating agent where X is as described in the specification. An alcohol preferably is added to the product solution is used to promote crystallization of the desired product.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.