Compounds, compositions and methods for the treatment of amyloid diseases such as systemic AA amyloidosis
US7601876B2 · kind B2 · utility
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Key dates
| Filing date | Mar 5, 2007 |
| Grant date | Oct 13, 2009 |
| Priority date | — |
| Expiry date | Sep 24, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D491/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, AA/SAA amyloidosis, such as observed in systemic AA amyloidosis and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.