Method of generating islet beta-cells from exocrine pancreatic cells
US7604991B2 · kind B2 · utility
4Cited by
1References
12Claims
0Family size
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Key dates
| Filing date | Jun 21, 2004 |
| Grant date | Oct 20, 2009 |
| Priority date | — |
| Expiry date | Oct 30, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2506/22
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention discloses an in vitro method wherein mammalian beta-cell differentiation can be induced in dedifferentiated exocrine pancreatic cells in a medium comprising ligands of the EGF receptor and the GP130 receptor, such as EGF and LIF. Insulin secreting cells, obtainable by this method, provide a means for the treatment of diabetes by islet transplantation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.