Synthesis of inhibitors of p90Rsk
US7605241B2 · kind B2 · utility
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6Claims
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Key dates
| Filing date | Jan 10, 2006 |
| Grant date | Oct 20, 2009 |
| Priority date | — |
| Expiry date | Apr 24, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H15/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The synthesis of the naturally occurring kaempferol glycoside SLO1O1-1, as well as analogs thereof, has been accomplished, as has its biochemical evaluation. SLO1O1-1 exhibits selective and potent p90 Rsk inhibitory activity at nanomolar concentrations without inhibiting the function of upstream kinases such as MEK, Raf, or PKC. The synthetic scheme of the invention verified the structural assignment of the natural product and has provided access to material sufficient for detailed biological evaluation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.