Methods and compositions for vaccination of animals with PRRSV antigens with improved immunogenicity
US7608272B2 · kind B2 · utility
5Cited by
2References
29Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 30, 2006 |
| Grant date | Oct 27, 2009 |
| Priority date | — |
| Expiry date | Aug 30, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2770/10034
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Pigs challenged with hypoglycosylated variants of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) major surface protein GP5 exhibited increased production of PRRSV-neutralizing antibodies relative to the levels of neutralizing antibodies produced by pigs immunized with wild type (wt) or glycosylated GP5. This invention provides for methods of obtaining improved immune responses in pigs to PRRSV, compositions useful for obtaining the improved immune responses as well as isolated polynucleotides that encode hypoglycosylated variants of PRRSV major surface protein GP5.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.