Urea or thiourea substituted 1,4-pyrazine compounds useful as anti-cancer agents and for inhibiting Chk1
US7608618B2 · kind B2 · utility
8Cited by
9References
2Claims
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Key dates
| Filing date | Apr 27, 2005 |
| Grant date | Oct 27, 2009 |
| Priority date | — |
| Expiry date | Mar 31, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D453/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds of the formulawherein: Y′ is O or S, W′ isoptionally substituted,Z′ is selected from the group consisting ofwherein Q′ is OR7 and R7 is C1-3alkyleneC3-8heterocycloalkyl useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division also are disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.