Imidazo[4,5-b]pyrazinone inhibitors of protein kinases

US7608622B2 · kind B2 · utility

Assignee

• Janssen Pharmaceuticals, Inc. · BE

Inventors

• Jian Liu · Xi'an, CN
• Raymond J. Patch · Yardley, US
• Mark R. Player · Phoenixville, US
• Huaping Hu · Pennington, US

Key dates

• Filing date: Sep 23, 2005
• Grant date: Oct 27, 2009
• Expiry date: Jan 14, 2027

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention is directed to compounds of Formula I:wherein Q, Y, A are set forth in the specification, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof, that inhibit protein kinases, especially Aurora-1, Aurora-2 and Aurora-3 kinases.