Process for the preparation on 2-aminomethylpyridine derivatives
US7608720B2 · kind B2 · utility
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3References
12Claims
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Key dates
| Filing date | Apr 26, 2004 |
| Grant date | Oct 27, 2009 |
| Priority date | — |
| Expiry date | Aug 29, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D213/61
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to a novel process for the preparation of 2-amino-methylpyridine derivatives of the formula (I), comprising reacting in a first step 2-substituted pyridine derivatives of the formula (II), with a nitroalkane of the formula (III), in the presence of a base resulting in 2-nitromethylpyridine derivatives of the formula (IV) and hydrogenating these 2-nitromethylpyridine derivatives of the formula (IV) in a second step in the presence of a catalyst and in the presence of an acid, where in the formulae n, X, Y, R1, R2 and A are as defined in the description.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.