Substituted indolepyridinium as anti-infective compounds

US7608726B2 · kind B2 · utility

Assignee

• Tibotec Pharmaceuticals Ltd. · IE

Inventors

• Bart Rudolf Romanie Kesteleyn · Berlare, BE
• Wim Van De Vreken · Haasdonk, BE
• Natalie Maria Francisca Kindermans · Mechelen, BE
• Maxime Francis Jean-Marie Ghislain Canard · La Hulpe, BE
• Kurt Hertogs · Antwerpen, BE
• Eva Bettens · Zoersel, BE
• Veronique Corine Paul De Vroey · Boechout, BE
• Dirk Jochmans · Leuven, BE

Key dates

• Filing date: Nov 14, 2003
• Grant date: Oct 27, 2009
• Expiry date: Apr 2, 2025

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/18
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention concerns the compounds of formula (I)their N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites, wherein n is 1, 2 or 3; R1is H, CN, halo, aminoC(═O), C(═O)OH, C1-4alkyloxyC(═O), C1-4alkylC(═O), mono- or di(C1-4alkyl)aminoC(═O), arylaminoC(═O), N-(aryl)-N—(C1-4alkyl)aminoC(═O), methanimidamidyl, N-hydroxy-methanimidamidyl, mono- or di(C1-4alkyl)methanimidamidyl, Het1 or Het2; R2 is H, C1-10alkyl, C2-10alkenyl, C3-7cycloalkyl, wherein said C1-10alkyl, C2-10alkenyl and C3-7cycloalkyl may be optionally substituted; R3 is nitro, cyano, amino, halo, hydroxy, C1-4alkyloxy, hydroxyC(═O), aminoC(═O), C1-4alkyloxyC(═O), mono- or di(C1-4alkyl)aminoC(═O), C1-4alkylC(═O), methanimidamidyl, mono- or di(C1-4alkyl)methanimidamidyl, N-hydroxy-methanimidamidyl or Het1; for use as a medicine. The invention further relates to a novel subgroup of the compounds of formula (I), and to compositions comprising compounds of formula (I).