1,4 O-linked saccharose derivatives for stabilization of antibodies or antibody derivatives

US7611709B2 · kind B2 · utility

Assignee

• BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG · DE

Inventors

• Stefan Bassarab · Biberach, DE
• Karoline Bechtold-Peters · Biberach, DE
• Richard Fuhrherr · Uetersen, DE
• Wolfgang Friess · Iffeldorf, DE
• Patrick Garidel · Norderstedt, DE
• Torsten Schultz-Fademrecht · Maselheim, DE

Key dates

• Filing date: May 2, 2005
• Grant date: Nov 3, 2009
• Expiry date: Apr 5, 2026

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K39/39591
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are applications of oligosaccharides/oligosaccharide mixtures for the production and stabilization of pharmaceutical compositions, chiefly powders, that contain antibodies or antibody derivatives as pharmaceutical active substance. The production of powders is accomplished through spray drying or freeze drying. Also disclosed are the corresponding antibody-containing powders as well as processes for their production.