Method for selecting allosteric regulators of class III G protein-coupled receptors
US7611848B2 · kind B2 · utility
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13Claims
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Key dates
| Filing date | May 11, 2004 |
| Grant date | Nov 3, 2009 |
| Priority date | — |
| Expiry date | May 11, 2024 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/02
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method for identifying and selecting a compound acting as an allosteric regulator of a GPCR-III is described. A method comparing the activity level of a recombinant GPCR-III (GPCR-III-Δ), essentially depleted of the extracellular domain of the corresponding native GPCR-III, in the presence of a given compound, with the activity level of the same GPCR-III-Δ is described. A method of identifying positive or negative allosteric regulators of GPCRs-III is described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.