Pyrrolidine bicyclic compounds and its derivatives, compositions and methods of use

US7612059B2 · kind B2 · utility

Assignee

• Vicuron Pharmaceuticals Inc. · US

Inventors

• Jeffrey W. Jacobs · Fremont, US
• Rakesh Patel · Princeton Junction, US
• Jason G. Lewis · Castro Valley, US
• Dinesh V. Patel · Fremont, US
• Zhengyu Yuan · Palo Alto, US

Key dates

• Filing date: Jun 13, 2005
• Grant date: Nov 3, 2009
• Expiry date: Aug 18, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

N-[1-oxo-(optionally 2-aza)-2-alkyl-3-(carboxyl or thiol or hydroxyaminocarbonyl or N-hydroxyformamido)-propyl]-(aryl or heteroaryl)-azacyclo4-7alkanes or thiazacyclo4-7alkanes, salts or prodrugs thereof have interesting properties, e.g., in the treatment or prevention of disorders amenable to treatment by PDF inhibitors, such as treatment of bacterial infections.