Mutants of the P4 protein of nontypable Haemophilus influenzae with reduced enzymatic activity
US7615229B2 · kind B2 · utility
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34Claims
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Key dates
| Filing date | Mar 13, 2003 |
| Grant date | Nov 10, 2009 |
| Priority date | — |
| Expiry date | Apr 28, 2025 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K39/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A P4 variant protein that has reduced enzymatic activity and that induces antibody to wild-type P4 protein and/or has good bactericidal activity against non-typable H. influenzae (NTHi) is useful as an active component in an immunogenic composition for humans. Methods of using these proteins, and compositions containing them in combination with additional antigens, are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.