Erastin and erastin binding proteins, and uses thereof

US7615554B2 · kind B2 · utility

Assignees

• Prolexys Pharmaceuticals, Inc. · US
• Whitehead Institute For Biomedical Research · US
• The Trustees of Columbia University in the City of New York · US

Inventors

• Robert Selliah · Fort Worth, US
• Longwu QI · Salt Lake City, US
• Paul Robbins · Gaithersburg, US
• Sudhir R. Sahasrabudhe · Wanchese, US
• Brent R. Stockwell · New York, US
• Raj Gopal Venkat · Salt Lake City, US

Key dates

• Filing date: Jan 25, 2006
• Grant date: Nov 10, 2009
• Expiry date: Jan 25, 2026

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/6872
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The invention relates to methods of screening for binding partners, especially binding partners essential for the biological activity of erastin (e.g. VDACs such as VDAC3). The invention also provides reagents and methods for effective killing of cancer cells with erastin and related compounds or derivatives.