Tetrahydro-naphthalene and urea derivatives

US7615557B2 · kind B2 · utility

Assignee

• Xention Limited · GB

Inventors

• Axel Bouchon
• Nicole Diedrichs · Wuppertal, DE
• Achim Hermann · Meldorf, DE
• Klemens Lustig · Wuppertal, DE
• Heinrich Meier · Wuppertal, DE
• Josef Pernerstorfer · Wuppertal, DE
• Elke Reissmuller
• Jean De Vry · Stolberg, DE
• Muneto Mogi · Waltham, US
• Klaus Urbahns · Kasai, JP
• Takeshi Yura · Nara, JP
• Hiroshi Fujishima · Nara, JP
• Masaomi Tajimi · Ebeye, US
• Noriyuki Yamamoto · Osaka, JP
• Yasuhiro Tsukimi · Kasai, JP
• Hiroaki Yuasa · Kizugawa, JP
• Jang Gupta · Kobe, JP
• Fumihiko Hayashi · Kizugawa, JP

Key dates

• Filing date: Sep 22, 2004
• Grant date: Nov 10, 2009
• Expiry date: Feb 21, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to a hydroxy-tetrahydro-naphthalene or an urea derivative formula (I) and salts thereof which are useful as active ingredients of pharmaceutical preparations, wherein A represents formula (II) or (III) wherein # represents the connection position to the molecule and Q1a, Q2a, Q3a and Q4a are defined, and E represents formula (IV) or (V) wherein # represents the connection position to the molecule and Q1b, Q2b, Q3b, Q4b, Q5b, R1b, na, ma, Xa and Ra are defined.