2-aminopyrimidine derivatives and their medical use

US7615562B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• Birgit Bollbuck · Munich, DE
• Alastair DenholmMritain · Horsham, GB
• Jorg Eder · Rheinfelden (Baden), DE
• Rene Hersperger · Münchenstein, CH
• Philipp Janser · Basel, CH
• Laszlo Revesz · Therwil, CH
• Achim Schlapbach · Bad Kötzting, DE
• Rudolf Wálchi · Basel, CH

Key dates

• Filing date: Apr 8, 2004
• Grant date: Nov 10, 2009
• Expiry date: Jul 27, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound of formula I or a pharmaceutically acceptable salt, ester or prodrug thereof wherein the variables have the meanings as defined in the specification. Further disclosed are a method of inhibiting IKK activity using a compound of formula I, a method of inhibiting production of TNF using a compound of formula I, a compound of formula I for use as a pharmaceutical, a pharmaceutical composition comprising a compound of formula I, and use of a compound of formula I in the manufacture of a medicament for use as an immunosuppressant or anti-inflammatory agent.