Modified interferon beta with reduced immunogenicity
US7615615B2 · kind B2 · utility
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3References
7Claims
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Key dates
| Filing date | Mar 17, 2008 |
| Grant date | Nov 10, 2009 |
| Priority date | — |
| Expiry date | Apr 24, 2028 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P37/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates a modified human interferon beta (INFβ) which is less immunogenic than human INFβ (SEQ ID NO: 1) when administered in vivo to a human. The modified human INFβ comprises an amino acid residue sequence that differs from SEQ ID NO: 1 by an amino acid residue substitution selected from the group consisting of L57A, L57C, L57D L57E, L57G, L57H, L57K, L57N, L57P, L57Q, L57R, L57S, and L57T and an additional substitution selected from the group consisting of the H140A, H140C, H140G, and H140P.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.