Methods, agents, and compound screening assays for inducing differentiation of undifferentiatied mammalian cells into osteoblasts
US7615626B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 23, 2006 |
| Grant date | Nov 10, 2009 |
| Priority date | — |
| Expiry date | Mar 18, 2027 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/108
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to methods, agents and compound screening assays for inducing differentiation of undifferentiated mammalian cells into osteoblasts. The invention thus provides a method, comprising contacting a compound with a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID No: 194-309; and measuring a compound-polypeptide property related to the differentiation of said cells. The invention further relates to a bone formation enhancing pharmaceutical composition, and the use thereof in treating and/or preventing a disease involving a systemic or local decrease in mean bone density in a subject. Furthermore, the invention relates to a method for the in vitro production of bone tissue.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.