Methods and compositions for detection of microbial contaminants in peritoneal dialysis solution
US7618392B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Jul 13, 2006 |
| Grant date | Nov 17, 2009 |
| Priority date | — |
| Expiry date | Nov 13, 2027 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/815
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods and compositions for detection of microbial contaminants in peritoneal dialysis solutions are provided. The methods and compositions employ modified bioburden testing and the detection of peptidoglycan. A novel cause of aseptic peritonitis is provided—aseptic peritonitis associated with gram positive microbial contamination of a dialysis solution. Peptidoglycan is a major component of a gram positive bacterial cell wall and thus can serve as a marker for gram positive bacteria. In this regard, testing for peptidoglycans can be utilized to effectively prevent peritonitis in patients that use the peritoneal dialysis solutions, such as peritoneal dialysis solutions that contain a glucose polymer including an icodextrin and the like.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.