Polymeric, degradable drug-eluting stents and coatings

US7618448B2 · kind B2 · utility

Assignee

• Tepha, Inc. · US

Inventors

• Klaus-Peter Schmitz · Rostock, DE
• Detlef Behrend · Jülich, DE
• Katrin Sternberg · Rostock, DE
• Niels Grabow · Rostock, DE
• David P. Martin · Arlington, US
• Simon F. Williams · Sherborn, US

Key dates

• Filing date: Feb 6, 2007
• Grant date: Nov 17, 2009
• Expiry date: Dec 2, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08K5/0083
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Absorbable stents and absorbable stent coatings have been developed with improved properties. These devices preferably comprise biocompatible copolymers or homopolymers of 4-hydroxybutyrate, and optionally poly-L-lactic acid and other absorbable polymers and additives. Compositions of these materials can be used to make absorbable stents that provide advantageous radial strengths, resistance to recoil and creep, can be plastically expanded on a balloon catheter, and can be deployed rapidly in vivo. Stent coatings derived from these materials provide biocompatible, uniform coatings that are ductile, and can be expanded without the coating cracking and/or delaminating and can be used as a coating matrix for drug incorporation.