Infectious cDNA clone of North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof
US7618797B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 25, 2006 |
| Grant date | Nov 17, 2009 |
| Priority date | — |
| Expiry date | Oct 25, 2026 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides isolated polynucleotide molecules that comprise a DNA sequence encoding an infectious RNA sequence encoding a genetically-modified North American PRRS virus, wherein the polynucleotide molecule lacks at least one detectable antigenic epitope of North American PRRS virus. The invention also provides vaccines comprising genetically modified North American PRRS virus, RNA molecules, plasmids and viral vectors comprising the isolated polynucleotide molecules. Also provided are isolated polynucleotide molecules further comprising at least one nucleotide sequence that encodes a detectable heterologous antigenic epitope, and vaccines comprising North American PRRS virus, RNA molecules, plasmids and viral vectors comprising such isolated polynucleotide molecules.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.