Patent · US Active

Pyroglutamate salts and their use in the optical resolution of intermediates for the synthesis of dextrocetirizine and levocetirizine

US7619085B2 · kind B2 · utility

0Cited by

1References

7Claims

0Family size

Assignee

UCB PHARMA S.A. · BE

Inventors

Magali Palacio · Brussels, BE
Celal Ates · Louvain-la-Neuve, BE

Key dates

Filing date	Feb 23, 2006
Grant date	Nov 17, 2009
Priority date	—
Expiry date	Nov 2, 2026

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D207/28
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention relates to (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide-(S)-pyrrolidone-5-carboxylic acid salt; (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide-(S)-pyrrolidone-5-carboxylic acid salt; (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide-(R)-pyrrolidone-5-carboxylicacid salt; or (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxycetamide-(R)-pyrrolidone-5-carboxylic salt. The present invention relates also to a process for preparing (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide (I) and (R)-2-[4-(4-chlorobenzhydryl) piperazin-1-yl]-ethoxyacetamide (II) by chemical resolution of a mixture. These compounds are respectively intermediates for the synthesis of dextrocetirizine and levocetirizine.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.