HIV integrase inhibitors

US7619086B2 · kind B2 · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• Matthew Morrissette · Las Vegas, US
• Peter D. Williams · Harleysville, US
• John S. Wai · Harleysville, US
• Thorsten E. Fisher · Hatfield, US
• Terry A. Lyle · Lederach, US

Key dates

• Filing date: Mar 4, 2005
• Grant date: Nov 17, 2009
• Expiry date: Oct 7, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication:wherein Z, R1, R2, R3, R4, R5, R6, R7, R8 and R9 are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.