Demethylation of 14-hydroxy substituted alkaloid derivatives
US7619088B2 · kind B2 · utility
1Cited by
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25Claims
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Assignee
Inventors
Key dates
| Filing date | Oct 29, 2008 |
| Grant date | Nov 17, 2009 |
| Priority date | — |
| Expiry date | Oct 29, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D489/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention is directed to a method for demethylating 14-hydroxy substituted alkaloid derivatives, in particular of 14-hydroxy-17-methyl-4,5-epoxymorphinane-6-on-derivatives. This is achieved by reacting a starting compound with a compound of general formula R1OOC—N═N—COOR2 in a suitable solvent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.