Trans-differentiation and re-differentiation of somatic cells and production of cells for cell therapies
US7621606B2 · kind B2 · utility
62Cited by
6References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 27, 2002 |
| Grant date | Nov 24, 2009 |
| Priority date | — |
| Expiry date | Aug 27, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2506/1307
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides a method for effecting the trans-differentiation of a somatic cell, i.e., the conversion of a somatic cell of one cell type into a somatic cell of a different cell type. The method is practiced by culturing a somatic cell in the presence of at least one agent selected from the group consisting of (a) cytoskeletal inhibitors and (b) inhibitors of acetylation, and (c) inhibitors of methylation, and also culturing the cell in the presence of agents or conditions that induce differentiation to a different cell type. The method is useful for producing histocompatible cells for cell therapy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.