Nitric oxide releasing prodrugs of diaryl-2-(5H)-furanones as cyclooxygenase-2 inhibitors
US7622501B2 · kind B2 · utility
14Cited by
1References
15Claims
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Key dates
| Filing date | Jan 25, 2005 |
| Grant date | Nov 24, 2009 |
| Priority date | — |
| Expiry date | Jul 16, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C317/46
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention encompasses novel compounds of Formula I, which are nitric oxide-releasing prodrugs of diaryl-2-(5H)-furanones useful in the treatment of cyclooxygenase-2 mediated diseases, Formula (I). The invention also encompasses certain pharmaceutical compositions and methods for treating cyclooxygenase-2 mediated diseases comprising the use of compounds of Formula 1. The above compounds may be used as a combination therapy with low-dose aspirin to treat chronic cyclooxygenase-2 mediated diseases or conditions while also reducing the risk of thrombotic cardiovascular events.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.