IL-14α RNA inhibitors and antibodies to IL-14α for treatment of autoimmune diseases and lymphomas

US7622574B2 · kind B2 · utility

Assignee

• The Research Foundation of the State University of New York · US

Inventors

• Julian L. Ambrus · Buffalo, US
• Long Shen · San Bernardino, US
• Richard Ford · Houston, US
• Chongjie Zhang · Sichuan, CN

Key dates

• Filing date: Oct 26, 2007
• Grant date: Nov 24, 2009
• Expiry date: Feb 28, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Provided are antisense poly-2′-O-(2,4-dinitrophenyl)oligoribonucleotides which are complementary to the IL-14α gene and/or transcribed IL-14α mRNA. Also provided are monoclonal antibodies reactive with discreet IL-14α peptides. The oligoribonucleotides and monoclonal antibodies are useful in inhibiting the growth of lymphocytes.