Method for inducing selectively suppressed immune response to transplanted tissue or cells
US7625557B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Aug 13, 2002 |
| Grant date | Dec 1, 2009 |
| Priority date | — |
| Expiry date | Apr 19, 2023 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61M1/3496
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Transimmunization methods incorporating skin immunologic challenges are described for either selectively suppressing the immune response of recipients of transplanted tissue or cells or monitoring induced anti-cancer immunity. In one embodiment, skin from the transplant donor is allografted to the transplant recipient to induce an immunological response to the transplanted skin. A quantity of blood is taken from the recipient and treated to render the T cells in the blood apoptotic and to induce differentiation of blood monocytes into dendritic cells. The treated blood is incubated and administered to the recipient to induce formation of suppressor T cell clones which reduce the number of T cells attacking the transplanted tissue or organ. This tolerogenic approach can be complemented by also feeding the immature dendritic cells apoptotic or necrotic cells from the organ donor. In a second embodiment, dendritic cells loaded with tumor antigens are injected intradermally to monitor the anti-cancer immunity induced by Transimmunization.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.