[1, 2, 4] Triazolo [1, 5-A] pyrimidine derivatives as chromatographic adsorbent for the selective adsorption of IGG

US7625838B2 · kind B2 · utility

Assignee

• GE Healthcare Bio-Science AB · US

Inventors

• Mathias Alterman · Stockholm, SE
• Andreas Axen · Uppsala, SE
• Enrique Carredano · Uppsala, SE
• Anna Gronberg · Uppsala, SE
• Jinyu Zou · Uppsala, SE

Key dates

• Filing date: Jun 17, 2009
• Grant date: Dec 1, 2009
• Expiry date: Jun 17, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Chemical engineering
• WIPO sector: Chemistry

Abstract

The present invention relates to a chromatographic adsorbent for selectively adsorbing IgG, comprising the following formulaand its corresponding enol-form, wherein X represents O, S, or NH; R1 represents H, C1-6 alkyl, C1-6 alkoxy, C1-6 alkoxy-C1-6 alkyl, Ar, —C(O)NHR3, —C(O)—R3 or halo; R2 represents H, C1-3 alkyl or halo; R3 represents H, C1-6 alkyl, C1-6 alkoxy, C1-6 alkoxy-C1-6 alkyl or Ar; n represents 0, 1, 2 or 3; Y represents a carrier. The present invention also relates to a method of producing said adsorbent as well as use thereof for separating substances by affinity chromatography.