Concentrate of a factor VIII:C-containing von Willebrand factor and the process relating thereto

US7625866B2 · kind B2 · utility

Assignee

• CSL Behring AG · DE

Inventors

• Gerhardt Kumpe · Wetter, DE
• Manfred Juraschek · Weimar, DE
• Natascha Mayer · Marburg, DE
• Stefan Schulte · Marburg, DE
• Wilfried Wormsbacher · Kirchhain, DE

Key dates

• Filing date: Sep 26, 2003
• Grant date: Dec 1, 2009
• Expiry date: Sep 26, 2023

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a concentrate and a process for producing a factor VIII:C-containing von Willebrand factor by fractional precipitation from a liquid comprising factor VIII:C and von Willebrand factor, resulting in an increased content of high molecular weight multimers of von Willebrand factor and a ratio of the vWF:RCoF activity to vWF:Ag of greater than 1.