Antisense antibacterial method and compound
US7625873B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 10, 2006 |
| Grant date | Dec 1, 2009 |
| Priority date | — |
| Expiry date | Aug 24, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/3233
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method and antisense compound for inhibiting the growth of pathogenic bacterial cells are disclosed. The compound contains no more than 12 nucleotide bases and has a targeting nucleic acid sequence of no fewer than 10 bases in length that is complementary to a target sequence containing or within 10 bases, in a downstream direction, of the translational start codon of a bacterial mRNA that encodes a bacterial protein essential for bacterial replication. The compound binds to a target mRNA with a Tm of between 50° to 60° C. The relatively short antisense compounds are substantially more active than conventional antisense compounds having a targeting base sequence of 15 or more bases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.