Pyrrole and pyrazole derivatives as potentiators of glutamate receptors

US7625932B2 · kind B2 · utility

Assignee

• ELI LILLY AND COMPANY · US

Inventors

• Pamela Albaugh · Carmel, US
• Esteban Dominguez-Manzanares · Alcobendas, ES
• Jian Hong · Shanghai, CN
• William J. Hornback · Indianapolis, US
• Delu Jiang · Carmel, US
• Paul Leslie Ornstein · Carmel, US
• Michelle Lee Thompson · Greenwood, US
• Eric George Tromiczak · Indianapolis, US
• Zhipei Wu · Fishers, US
• Hamideh Zarrinmayeh · Carmel, US
• Dennis M. Zimmerman · Mooresville, US
• Ana Castano Mansanet · Alcobendas, ES
• Larry Gene Huffman · Indianapolis, US
• William David Miller · Indianapolis, US

Key dates

• Filing date: Aug 27, 2004
• Grant date: Dec 1, 2009
• Expiry date: Feb 22, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to pyrrole and pyrazole compounds of formula (I) and their pharmaceutically acceptable salts, and further relates to their use in treating schizophrenia, cognitive deficits associated with schizophrenia, Alzheimer's disease, dementia of the Alzheimer's type, mild cognitive impairment, or depression. The compounds act as potentiators on glutamate receptors, in particular AMPA and the GluR family.