Patent · US Active

Indoles having anti-diabetic activity

US7625933B2 · kind B2 · utility

2Cited by

3References

17Claims

0Family size

Assignee

MERCK & CO., INC. · US

Inventors

Kun Liu · Edison, US
Peter T. Meinke · New York, US
Harold B. Wood · Westfield, US

Key dates

Filing date	Jun 28, 2005
Grant date	Dec 1, 2009
Priority date	—
Expiry date	Oct 13, 2026

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D413/10
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Indoles of Formula I having —X-aryl-(CH2)x-oxazolidinedione and —X-heteroaryl-(CH2)x-oxazolidinedione substituents on the N atom of the indole ring, where x is 0 or 1, and —X— is a bond or —CH2—, and their thiazolidinedione analogs, are PPAR gamma agonists or partial agonists and are useful in the treatment and control of type II diabetes, including hyperglycemia, dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.