Substituted 3-(diarylmethylene)indolin-2-ones and methods of their use
US7626031B2 · kind B2 · utility
5Cited by
10References
19Claims
0Family size
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Key dates
| Filing date | Nov 14, 2003 |
| Grant date | Dec 1, 2009 |
| Priority date | — |
| Expiry date | Apr 27, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D451/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides oxindole derivatives which inhibit, regulate and/or modulate kinase receptor, particularly VEGF receptor 2 (Flk-1/KDR), FGFR1, and PDGFR (alpha and beta), signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.