Outer membrane vesicles and uses thereof
US7628995B2 · kind B2 · utility
29Cited by
0References
8Claims
0Family size
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Key dates
| Filing date | Dec 21, 2004 |
| Grant date | Dec 8, 2009 |
| Priority date | — |
| Expiry date | Jul 29, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention discloses a Gram negative bacterium in which the expression of a protein involved in LPS transport to the outer membrane is functionally downregulated such that the level of LPS in the outer membrane is decreased compared to a wild-type Gram negative bacterium. Down regulation of Imp and MsbA proteins can result in such a bacterium. Outer membrane vesicle preparations derived from the Gram negative bacterium of the invention can be used in vaccines to provide protection against bacterial infection.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.