Sterile immunogenic non-tumorigenic tumor cell compositions and methods
US7628996B2 · kind B2 · utility
3Cited by
18References
17Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 21, 2003 |
| Grant date | Dec 8, 2009 |
| Priority date | — |
| Expiry date | May 11, 2024 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/55594
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to methods of removing bioburden from an aggregate of cells to obtain sterile cells that remain viable and immunogenic for the production of vaccines. This invention further relates to a method of eliciting an immune response to prevent a recurrence of metastases that involves preparing and administering a sterile vaccine derived from solid tumors. The vaccine is prepared by excising a solid tumor from a cancer patient, digesting the tumor cells with an enzyme to obtain dissociated cells, irradiating the dissociated cells to render the cells non-tumorigenic, and sterilizing the cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.