Sequential analysis of biological samples

US7629125B2 · kind B2 · utility

Assignee

• General Electric Company · US

Inventors

• Anup Sood · Flemington, US
• Michael Christopher Montalto · Albany, US
• Michael John Gerdes · Albany, US
• Maximilian Lewis Seel · Boston, US
• Robert John Filkins · Niskayuna, US

Key dates

• Filing date: Nov 16, 2006
• Grant date: Dec 8, 2009
• Expiry date: Sep 12, 2027

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T436/143333
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Methods for detecting multiple targets in a biological sample are provided. The methods includes contacting the sample with a first probe; physically binding the first probe to a first target; observing a first signal from the first probe; applying a chemical agent to modify the first signal; contacting the sample with a second probe; physically binding the second probe to a second target; and observing a second signal from the second probe. The methods disclosed herein also provide for multiple iterations of binding, observing, signal modification for deriving information about multiple targets in a single sample. An associated kit and device are also provided.