Ketoreductase polypeptides and related polynucleotides
US7629157B2 · kind B2 · utility
30Cited by
10References
11Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 11, 2004 |
| Grant date | Dec 8, 2009 |
| Priority date | — |
| Expiry date | Oct 13, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N9/0006
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention is directed to variant polypeptides having enhanced ketoreductase activity and/or thermostability for use in the stereospecific reduction of ketones. In addition, the present invention is directed to polynucleotides that encode the ketoreductase polypeptides, including codon optimized versions of the polynucleotides which provide for enhanced expression in host cells. In another aspect, the present invention is directed to nucleotide constructs, vectors and host cells that are transformed with polynucleotides of the present invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.