Method for identifying agents that interact with beta-site APP cleaving enzyme (BACE)
US7630838B2 · kind B2 · utility
6Cited by
7References
16Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 19, 2001 |
| Grant date | Dec 8, 2009 |
| Priority date | — |
| Expiry date | Nov 2, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/02
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
This invention is directed to the three dimensional crystal structure of Beta-site APP Cleaving Enzyme (BACE), and to the use of this structure in rational drug design methods to identify agents that may interact with active sites of BACE. Such agents may represent new therapeutics in the treatment and/or prevention of Alzheimer's Disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.